Careers

We are currently based in Stevenage, UK and Ambler, PA in the US. Our team is expanding.  We provide extraordinary career opportunities for talented individuals, who will have the opportunity to work with highly experienced leaders in science and business with proven track records in building successful businesses.  Our success depends on the quality, experience and ambition of the individuals that join our team.

This is an opportunity to help build Gyroscope into a world class gene therapy company, so if you would like to become a part of our dynamic team and contribute towards preventing the devastating impact of sight loss, please contact: recruitment@gyroscopetx.com

Gyroscope is an equal opportunity employer committed to a culturally diverse and international team.

Please note that Gyroscope does not accept speculative applications from recruitment agencies.

Open Positions

To take the next exciting step in your career, please review our list of current openings and job descriptions below. To apply, please submit your CV and a cover letter to recruitment@gyroscopetx.com

Gyroscope does not accept speculative applications from recruitment agencies.

 

Location: Ambler, PA

About Us

Gyroscope Therapeutics is a clinical-stage retinal gene therapy company, developing cutting edge medicines to treat eye diseases linked to a part of the immune system called the complement system. The company was founded to capitalize on a convergence of advancements made in the understanding of the complement system’s impact on eye disease, the genetic basis of Age-related Macular Degeneration (AMD) and gene therapy as a mode of treatment delivery.

Recently, Gyroscope Therapeutics merged with Orbit Biomedical to create the first fully integrated retinal gene therapy company with a promising investigational medicine, high quality manufacturing and a surgical platform that can support accurate, safe and consistent delivery to patients with blinding conditions.

Gyroscope’s lead investigational medicine, GT005 is being studied in the Phase I/II FOCUS trial in advanced dry AMD. GT005 is a novel retinal gene therapy that delivers a targeted, single dose treatment for the progressive visual impairment caused by dry AMD in patients by locally modulating complement activity. Gyroscope is building a pipeline of medicines for blinding eye diseases linked to the complement system.

Orbit Biomedical Inc., is a medical device company and subsidiary of Gyroscope, operating at the intersection of gene and cell therapy, engineering technology and surgeon education. Our goal is to revolutionize gene and cell therapy treatment by setting a new standard for precise, targeted surgical delivery.  Orbit Biomedical’s technology, the result of many years’ work, is designed to safely and consistently deliver gene and cell therapy medicines, initially for the treatment of retinal disease. Orbit plans to use its proprietary delivery system to support accurate, safe and consistent delivery of Gyroscope gene therapy technologies and to partner with external companies who are developing single-use cell and gene therapies.

We are at the beginning of an incredible journey and are looking for a passionate R&D professional to join our team.

Scope of role

The Orbit Team is recruiting for a top executive responsible for overseeing the overall product development/ engineering functions on a global basis for medical device engineering and product development. Responsibilities include overseeing the creation, development and design of all the company’s engineered products, engineering services, and device research function.

What you will be doing:

  • Inspire a team to advance the product pipeline and bring new products to market
  • Oversee the selection of research projects to insure they have the potential to add value
  • Design and execute a comprehensive R&D plan for the development of the company’s proprietary technologies
  • Collaborates with other functions in the company to ensure that products meet the required legal, regulatory and medical/health requirements
  • Identify new collaborative technology opportunities with leading industry partners
  • Provide technological leadership in defining the company’s corporate strategies and plans
  • Develop and execute the R&D team’s goals and objectives to achieve the plans and timelines
  • Manage the R&D budget and capital expenditures
  • Lead the R&D team and develop the company’s R&D talent
  • Foster a highly dynamic and interactive working environment
  • Grow the R&D organization by recruiting critical engineering talent and managing expansion of technical resources
  • Monitor competing and complementary technologies and companies for potential licensing or M&A activities
  • Lead various stages of product development as well as cross-functional activities
  • Bring past experience and knowledge to proactively identify potential pitfalls and challenges to all projects and products
  • Create new products and processes based on prior experience
  • Help to manage and enhance the company’s intellectual property portfolio
  • Work with external vendors and develop solid collaborations and partnerships that grow the organization
  • Professionally represent and present company technology and products to healthcare professionals, government agencies, academic and industry partners and investor groups at congresses and meetings

What we want to see in your professional career:

  • Advanced Degree in Mechanical, Biomedical or Electrical Engineering and/or equivalent relevant experience
  • Demonstrable experience in medical device R&D within a hands-on management role
  • Thorough understanding of all stages of medical surgical device product development and market introduction
  • Strong ability to apply knowledge and provide imaginative solutions to difficult problems
  • Fundamental understanding of gene therapy, cell therapy and drug development
  • Knowledge of FDA, GMP, and combination product requirements
  • Experience with ophthalmic device design and manufacturing a plus
  • Proficiency with 3D solid modeling software, MS Office, and analytical/statistical software
  • Excellent written and verbal communications skills
  • Experience of working within a diverse team in Europe and USA
  • Ability to manage multiple projects simultaneously
  • Can travel internationally for up to two-week periods

If you would like to discuss this position, please forward your resume to recruitment@gyroscopetx.com or s.bassi@gyroscopetx.com .

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Location: Stevenage

 

Details:

Gyroscope’s process development (PD) team is being expanded to develop and support an increasing portfolio of gene therapy medicines. The team is responsible for delivering  optimised platforms for the production of adeno associated viruses (AAV) for clinical and subsequent commercial use. The main focus of the role will be upstream processing of viral vectors, but some experience of downstream processing would also be an advantage. The chosen candidates will help to support aspects of the internal viral vector upstream suspension cell culture platform development and technology transfer to contract manufacturing organisations (CMOs) to support early clinical phases and the subsequent transition to late stage development and manufacture. The role will help to initiate and support the development of innovative improvements in the manufacture of cell and gene therapy medicines.

Gyroscope is seeking a highly motivated and creative individual to work within the PD team. The successful candidate will use their understanding  of both upstream processing and bioprocess engineering to develop and implement robust unit operations for the manufacture of vector for clinical gene therapy.

This role will give the chosen candidate an exciting opportunity to take novel and creative approaches to improving upon current state-of-the-art AAV production technology and subsequent application within a team that is applying AAV vectors to the transformational treatment of human disease. Experience in some or all of the following techniques would be an advantage: Suspension cell culture, bioreactors and scale-up, transient transfection, processing of crude harvest, filtration and clarification plus downstream processing experience.

 

The successful candidates will join a rapidly growing world-class team and will have the opportunity to play a part in shaping the growth of this exciting expanding clinical stage biotechnology start-up

Activities:

  • Optimisation of process parameters to increase yield in upstream processing
  • Testing of novel plasmid constructs designs to enhance AAV production
  • Conducting experiments to support definition of process ranges and unit operation definition and selection
  • Independent working and ability to lead work packages and matrix manage others if/as required
  • Ensuring all required documentation and experimental write-ups are completed and approved in a timely manner
  • Support/Lead USP tech transfer of early and late phase clinical stageprocess to chosen CMO
  • To ensure validity and reliability of data at all times
  • To prepare material for presentation, patent filings and manuscripts for publication
  • To present findings to colleagues in lab meetings
  • To assist in the supervision of technicians and junior researchers
  • Writing research operating procedures and reports as required
  • Provide support for meeting management, action follow-up to ensure adherence to agreed milestones
  • Cross-functional working with other departments in Gyrsocope
  • Management and scientific oversight of external programmes

Basic Qualifications (some or all competencies below need to be met)

 

  • PhD or BSC with equivalent experience considered with background in biochemical engineer or related biological discipline
  • Experience of adherent and suspension cell culture production of biopharmaceutical or viral vectors
  • Ability to work to priorities and deliver projects on time
  • High level analytical capability
  • Ability to communicate complex information clearly
  • Ability to apply relevant models, techniques and methods and develop new ones
  • Ability to encourage research culture in others

 

Preferred qualifications:

 

  • Knowledge of interactions between viruses and physical and chemical conditions
  • Understanding of the drug development process ideally for biopharmaceutical or cell/gene therapy products

 

The application should include a one page letter outlining how you meet the required competencies for this role at Gyroscope Therapeutics as outlined in the job requirements above. This letter should be accompanied by a two page C.V.  Interested applicants should submit their applications to t.senussi@gyroscopetx.com.

Apply +

Location:

Stevenage

 

Details:

Gyroscope’s analytical development team is being expanded to develop state of the art methods for the characterisation of the company’s increasing portfolio of gene therapy medicines. The team is responsible for method development to support characterisation of AAV vectors and transgene proteins. As a result, Gyroscope is seeking a talented analytical development scientist with experience in molecular biological, immunoassay, and protein separation.

 

The chosen candidate will help to support aspects of the projects from early phases and the subsequent transition to clinical development, to underpin and support subsequent manufacture and characterisation of Gyroscope’s products. The role will help to initiate and support the development of innovative improvements in the design, characterisation and manufacture of cell and gene therapy medicines.

 

This role will give the chosen candidate an exciting opportunity to take novel and creative approaches to improving upon current state-of-the-art AAV characterisation methods and subsequent application within a team that is applying AAV vectors to the transformational treatment of human disease.

 

The successful candidate will join a rapidly growing world-class team and will have the opportunity to play a part in shaping the growth of this exciting biotechnology company.

Activities:

  • Develop, implement, and employ state of the art characterisation of AAV vectors and transgene proteins by a number molecular biological methods and immunoassays
  • Evaluate assay performance and select methods capable to support QC release of Gyroscope’s products
  • Conducting assay development experiments to support process development activities
  • Ensuring all required documentation and experimental write-ups are completed and approved in a timely manner
  • Ensure validity and reliability of data at all times
  • Writing analytical development procedures and reports as required
  • Present results internally and externally
  • Support tech transfer to third parties and assay validation as required
  • Support creation of regulatory submission documents
  • Provide support for meeting management, action follow-up to ensure adherence to agreed milestones
  • Cross-functional working with other departments in Gyroscope
  • Management and scientific oversight of external programmes

Basic Qualifications (all competencies below need to be met)

  • OR MSc. OR PhD in biotechnology, molecular biology or related discipline
  • A background in recombinant protein OR antibody OR vaccine analytical development OR QC, with 1 to 5 or more years’ experience gained in industry (depending on qualification).
  • Hands on expertise in development of qPCR, ELISA, and SDS PAGE method development.
  • Experience with DoE approach for method development
  • Ability to work to priorities and deliver projects on time
  • Strong analytical and data interpretation capability
  • Ability to communicate complex information clearly
  • Ability to apply relevant models, techniques and methods and develop new ones
  • Ability to assess resource requirements and deploy them effectively
  • Ability to encourage a “quality by design” culture in others

Preferred qualifications:

  • Experience in one or more of the following techniques: cell culture, multiplex qPCR, ddPCR, SDS-PAGE, Western Blotting, Southern Blotting, and agarose gel electrophoresis, capillary electrophoresis, mass spectrometry
  • Experience in oversight of CMOs/CROs
  • Knowledge of GMP, method transfer, and regulatory submission documents
  • Knowledge and experience of the molecular biology of adeno-associated viruses (AAV)

The application should include a one page letter outlining how you meet the required competencies for this role at Gyroscope Therapeutics as outlined in the job requirements above. This letter should be accompanied by a two page C.V. Interested applicants should submit their applications to recruitment@gyroscopetx.com

 

Note to applicants:

Gyroscope will respond to applicants within four weeks of submitting your application. Should you not hear from Gyroscope within that time please consider your application unsuccessful at this time. If you wish to obtain feedback why your application was unsuccessful please contact Gyroscope using the e-mail address stated above.

Note to recruitment agencies:

This vacancy is not open to any agency. Please do not provide CVs unless specifically requested to do so.

Apply +

Location:

Stevenage

 

Details:

Gyroscope’s analytical development team is being expanded to develop state of the art methods for the characterisation of the company’s increasing portfolio of gene therapy medicines. The team is responsible for method development to support characterisation of AAV vectors and transgene proteins. As a result, Gyroscope is seeking a talented analytical development scientist with experience in chromatography and electrophoresis based analysis of proteins.

 

The chosen candidate will help to support aspects of the projects from early phases and the subsequent transition to clinical development, to underpin and support subsequent manufacture and characterisation of Gyroscope’s products. The role will help to initiate and support the development of innovative improvements in the design, characterisation and manufacture of cell and gene therapy medicines.

 

This role will give the chosen candidate an exciting opportunity to take novel and creative approaches to improving upon current state-of-the-art AAV characterisation methods and subsequent application within a team that is applying AAV vectors to the transformational treatment of human disease. Experience in some or all of the following techniques is essential: Hands on expertise of CE and HPLC/UHPLC bioseparations and relevant molecular biology techniques due to expectation to work across analytical development team.

 

The successful candidate will join a rapidly growing world-class team and will have the opportunity to play a part in shaping the growth of this exciting biotechnology company.

Activities:

  • Develop, implement, and employ state of the art characterisation of AAV vectors and transgene proteins by a number of chromatography and electrophoresis based methods
  • Evaluate assay performance and select methods capable to support QC release of Gyroscope’s products
  • Conducting assay development experiments to support process development activities
  • Ensuring all required documentation and experimental write-ups are completed and approved in a timely manner
  • Ensure validity and reliability of data at all times
  • Writing analytical development procedures and reports as required
  • Present results internally and externally
  • Support tech transfer to third parties and assay validation as required
  • Support creation of regulatory submission documents
  • Provide support for meeting management, action follow-up to ensure adherence to agreed milestones
  • Cross-functional working with other departments in Gyroscope
  • Management and scientific oversight of external programmes

Basic Qualifications (all competencies below need to be met)

  • OR MSc. OR PhD in biochemistry, protein engineering, molecular biology or related discipline
  • A background in recombinant protein OR antibody analytical development OR QC, with 1 to 5 or more years’ experience gained in industry (depending on qualification).
  • Hands on expertise of CE and/or HPLC/UHPLC (at least 2 separation modes, e.g. size exclusion, ion exchange, reverse phase, hydrophobic interaction) and SDS PAGE of proteins.
  • Experience with DoE approach for method development
  • Ability to work to priorities and deliver projects on time
  • Strong analytical and data interpretation capability
  • Ability to communicate complex information clearly
  • Ability to apply relevant models, techniques and methods and develop new ones
  • Ability to assess resource requirements and deploy them effectively
  • Ability to encourage a “quality by design” culture in others

Preferred qualifications:

  • Experience of capillary electrophoresis (CE SDS), gel based IEF, imaging capillary IEF, Western blotting and mass spectrometry
  • Experience in oversight of CMOs/CROs
  • Knowledge of GMP, method transfer, and regulatory submission documents
  • Knowledge and experience of the molecular biology of adeno-associated viruses (AAV)

The application should include a one page letter outlining how you meet the required competencies for this role at Gyroscope Therapeutics as outlined in the job requirements above. This letter should be accompanied by a two page C.V. Interested applicants should submit their applications to recruitment@gyroscopetx.com

 

Note to applicants:

Gyroscope will respond to applicants within four weeks of submitting your application. Should you not hear from Gyroscope within that time please consider your application unsuccessful at this time. If you wish to obtain feedback why your application was unsuccessful please contact Gyroscope using the e-mail address stated above.

Note to recruitment agencies:

This vacancy is not open to any agency. Please do not provide CVs unless specifically requested to do so.

Apply +

Open position for Research Assistant in an innovative gene therapy company

R&D group in a start-up gene therapy biotech company is currently seeking a highly motivated Research Assistant.

The successful candidate will join Gyroscope’s highly active research team which is responsible for the delivery of novel adeno-associated virus (AAV) construct designs and early in vitro and in vivo proof-of-concept studies (PoC) for candidates in pre-clinical development. He or she will support all aspects of the projects from early phases and the subsequent transition to clinical development, as well as supporting subsequent small-scale vector manufacture and testing. The role will involve supporting the initiation and subsequent development of innovative improvements in the design, characterisation and manufacture of gene therapy medicines.

Gyroscope’s mission is to develop genetically-defined therapies for the treatment of eye diseases linked to an unbalanced complement system. The company has built up a highly experienced and cross-disciplinary team and is developing cutting edge therapies for eye diseases with unmet medical need.

The position will be based in Stevenage, Hertfordshire, UK.

Required skills

  • Experience in cloning, PCR, agarose gel electrophoresis;
  • Experience in performing assays such as western blotting and ELISA;
  • Experience in cell and tissue culture, working under aseptic conditions;
  • Preparation and maintenance of accurate laboratory records.
  • Excellent organisational skills (more…)
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