Careers

We are currently based in Stevenage, UK and Ambler, PA in the US. Our team is expanding.  We provide extraordinary career opportunities for talented individuals, who will have the opportunity to work with highly experienced leaders in science and business with proven track records in building successful businesses.  Our success depends on the quality, experience and ambition of the individuals that join our team.

This is an opportunity to help build Gyroscope into a world class gene therapy company, so if you would like to become a part of our dynamic team and contribute towards preventing the devastating impact of sight loss, please contact: recruitment@gyroscopetx.com

Gyroscope is an equal opportunity employer committed to a culturally diverse and international team.

Please note that Gyroscope does not accept speculative applications from recruitment agencies.

Open Positions

To take the next exciting step in your career, please review our list of current openings and job descriptions below. To apply, please submit your CV and a cover letter to recruitment@gyroscopetx.com

Gyroscope does not accept speculative applications from recruitment agencies.

 

Location: London (Kings Cross)

The Finance Business Partner – UK is responsible for providing financial advice, challenge and support to the business management of Gyroscope, in order to help drive and monitor the business in line with its strategy over the long term, as well as against in-year budget targets.

The scope of the role is the full group operations of Gyroscope including the consolidated plan for the full group, plus a specific focus on business partnering with any activities operated in the UK.

The Finance Business Partner – UK interacts closely with the Extended Leadership Team, the Finance Business Partner – US and the Financial Accounting Team.   He/she will ensure the production of high quality and insightful management information, both historic and forward looking.    External interactions include auditors, key suppliers, and key customers in due course. 

Key Accountabilities:

Planning

  • Ensure financial considerations and constraints are taken into account in setting strategic direction
  • Ensuring optimal resource allocation in the short and long term, including cost control, ad hoc investment analysis, understanding operational variances
  • Leading the planning process (budgets, forecasts) for the company, including preparation of P&L, Balance Sheet and Cashflow forecasts, and preparation of funding proposal documents ahead of each funding round.
  • Providing financial management information to business management, whether via standard reports directly out of the ERP, or specific analysis
  • Development and maintenance of budgeting and planning tools

Analysis

  • Develop fit-for-purpose reporting from the Gyroscope ERP system, including project /cost centre/ divisional reporting
  • Providing financial management information to business management, whether improving reports directly out of the ERP, or specific analysis or management reports
  • Interacts with Accounting & Reporting team to ensure the accuracy of monthly financial data and balance sheet integrity, monitoring and reviews accruals, reserves and balance sheet reconciliations
  • Work closely with the FBP – US to ensure that seamless, high quality management information is generated on a timely basis, both historic and forward looking

Other

  • Support the R&D Tax Credit administration and claims process
  • Supports a well-controlled procurement process
  • Development and maintenance of finance policies and controls
  • Support ERP implementation and future developments to ensure fit for purpose in terms of planning and analysis needs 

Education and Qualifications:

Bachelor’s degree in business or finance; CPA/ACA strongly preferred. Must have demonstrated experience as a senior finance business partner and/or Finance Business Partner – UK.    Experience within start-ups or small companies is preferred.

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Location: Ambler, PA

Gyroscope Therapeutics is developing gene therapy beyond rare disease and using it to treat a leading cause of blindness, dry age-related macular degeneration (dry-AMD). Currently, 35 million people are affected by dry-AMD around the world and there are no approved treatments.

Our investigational therapy, GT005, is designed to restore balance to a part of our immune system called the complement system. The goal is to slow, or possibly stop the progression of dry-AMD. Patients in our Phase I/II clinical trial receive a single dose therapy through a one-time procedure into the back of their retina.

We are looking for Senior Clinical Project Managers who will work as the lead Study/Program Operational Clinical Project Manager, support the design, planning and execution of assigned clinical studies to support product development, regulatory submissions and post-market evaluation.

The Senior Clinical Project Manager will be responsible for clinical operational oversight as well as the execution of all assigned studies, monitoring of study deliverables, performing protocol-related site management activities, participating in study planning and set-up activities including vendor management, project management, coordination of study and implementation plans and supporting third party vendor relationships.

What we want to see in your professional experience:

  • Responsible for the oversight and day-to-day management of clinical operations activities e.g. budgets, milestones, deliverables and timelines, for one or more clinical studies
  • Responsible for the oversight and management of fully outsourced clinical studies from protocol development through to clinical study report
  • Ensure that the planning, implementation, coordination and reporting of the clinical studies in line with the corporate objectives
  • Act as the key study contact for studies and effectively plan and communicate study milestones, deliverables, timelines and quality standards to project team and other stakeholder groups
  • Support and monitor CRO and third-party vendor activities, including study set-up, project management, monitoring, data management, biostatistics and clinical study report
  • Monitor progress of studies, identify study-related trends/issues and work with the Director of Clinical Operations and CRO to implement corrective actions when necessary
  • Travel to include attendance at Vendor Meetings, Investigator Meetings, Society Meetings, recruitment motivational visits and to conduct co-evaluation visits with CRO monitors
  • Prepare and/or review Study Plans, Vendor Specifications and Scopes of Work
  • Contribute to the preparation, design and/or review of essential regulatory study documents, ethics and other required local/national submission requirements
  • Drive the identification and selection of clinical trial investigators as per clinical operations strategy
  • Review and maintain QMS for clinical programs
  • In conjunction with Surgical Liaison/Director of Clinical Operations develop Surgical Manual and Training Plan
  • In conjunction with Project Director, develop and maintain Study Risk Management Plan
  • Coordinate with CMC for the shipment of IP and ancillary supplies to investigator sites
  • Work with Research Dept and specialist laboratory vendors to ensure clinical biological sample collection, shipment, storage and analysis
  • Coordinate and lead contract and budget negotiations with sites and third party vendors
  • Lead study operational and/or scientific feasibility, and site set-up activities as per clinical operations strategy
  • Prepare study training materials and present at Monitors Workshops and Investigator Meetings
  • Maintain study trackers to provide financial and management accountability
  • Set up and chair study meetings, including DSMB, Steering Committee and/or Advisory Board
  • Act as Sponsor representative and key point of contact for Investigators, KOLs and other external parties
  • Ensure study certifications, insurance, licenses and registrations are maintained
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Location: Stevenage for 3 days and 2 days from home. Can work from London Office for 1-2 days.

Gyroscope Therapeutics is looking for Senior Clinical Project Managers who will work as the lead Study/Program Operational Clinical Project Manager, support the design, planning and execution of assigned clinical studies to support product development, regulatory submissions and post-market evaluation.

The Senior Clinical Project Manager will be responsible for clinical operational oversight as well as the execution of all assigned studies, monitoring of study deliverables, performing protocol-related site management activities, participating in study planning and set-up activities including vendor management, project management, coordination of study and implementation plans and supporting third party vendor relationships.

What we want to see in your professional experience:

  • Study set-up and management of global phase I-III studies including study set-up, project management, monitoring, data management, bio-statistics and clinical study report
  • Site, CRO and vendor management experience
  • Evidence & experience of your input into study design
  • Writing key study documents contributing to the preparation, design and/or review of essential regulatory study documents, ethics and other required local/national submission requirements
  • Demonstrable experience of regulatory and ethics submissions
  • Management of study contracts and budgets including maintaining study trackers to provide financial and management accountability
  • Pharmacovigilance & Safety monitoring experience
  • Data Management and monitoring

It would be great to see (but not essential):

  • ATMP/GMO/Biologics handling
  • Working within a small to mid-sized biotech
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Location: Stevenage/travel to London Office (Kings Cross)

You have worked for small to mid-sized companies and love what  you do but feel that you  need an opportunity to build some thing from scratch, where the real value of what you can do  shows and is appreciated.  The mission and value of what you are doing is still important but somewhere along the way you have realised that you want to work with a company when it is at its infancy and you want to give it the benefit of your experience, skills and wisdom. You want to get that energy, when you were at your peak, back. Read on, this might be serendipitous.

Scope 

The Associate Director/Director for IT will be responsible for the IT operations and strategy that ensures that IT services meet the requirements of our fast growth business in UK and US. This will include a wide range of activities, from the strategic review of our service deployment, to managing major incidents and diving into desktop user support needs. The successful candidate will have brilliant knowledge of best practice process in IT service delivery, be a hands-on problem solver, have the ability to lead from the front and to communicate effectively with multiple stakeholders.

The primary purpose of this role being to ensure that a high performance, robust and resilient IT infrastructure is provided to the business, focusing on the global internal customer experience. This is a hands-on role which includes the operations, strategy and execution which means, for example, that on any day you may be setting up equipment to having vendor meetings to presenting to the leadership on your plan.

Responsibilities:

  • Ownership and accountability for the IT operations and strategy and global IT infrastructure including networking, telephony, internal systems, technical support and asset management.
  • Coordinating the workload and workflow of the IT Department effectively.
  • Evaluating user needs and system functionality, to ensure that IT facilities remain fit for purpose.
  • Proactively ensuring the highest levels of systems and infrastructure availability
  • Managing ‘crisis’ situations, which may include complex hardware or software problems.
  • Provide direction and in particular drive forward new and existing IT department projects
  • Participate in the design of information and operational support systems and be fully hands-on
  • Developing, managing and delivering effective IT strategies.
  • Identifying and implementing technology to innovate and improve key business processes.
  • Managing a consistent platform for all user software, hardware and databases that is stable, secure, reliable and scalable as the business grows.
  • Managing the IT department’s workload to ensure IT issues are resolved within agreed SLAs using KPIs and other objectives and measures.
  • Preparing and managing the annual IT budget.
  • Managing all outsourcing and supplier relationships.
  • Serves as focal point for all inter-office IT-related matters company-wide.

What we look for in your skills and experience:

  • Experience of working in a very fast-moving global organisation
  • Excellent and proven technical skills across Microsoft technologies
  • IT Infrastructure and Communications proficiency: Microsoft Environments (SharePoint, Windows Server, Exchange, Active Directory,…), Networking (routing, switching, LAN, WAN…)
  • Hands on – can troubleshoot and resolve technical issues not matter how small
  • Excellent communication skills, written and oral and the ability to tailor that communication to both technical and non-technical audiences.
  • Bachelor’s Degree in Computer Science, Information Systems, Engineering, Business or technical discipline or relevant experience
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Location: London (Kings Cross)

The Complement Expert will act as scientific lead for New Target Identification, develop and refine new complement-based assays and will coordinate assay development activities across project boundaries with other functional areas within Research. The expectation is that this individual will represent Research on project teams. The successful candidate will have the ability to complete work in a resourceful, self-sufficient manner and is able to design research projects to achieve desired outcomes.

Key Responsibilities:

  • Responsible for scientific insights related to driving new target discovery, understanding of mechanism of action, and rationale for indication expansion
  • Represent Research within multidisciplinary project teams
  • Contributes to technical assessment as part of due diligence activities
  • Participates in the selection of CROs and academic collaborators via technical assessments
  • Collaborates with project team to develop study designs
  • May assist in the preparation of internal documents and Regulatory submissions, including authoring (under supervision)
  • Performs other duties as assigned

What we look for in your skills and experience:

  • Proven track record in identifying and validating targets within Complement biology
  • Possesses a distinguished record enabling the goals of the assigned projects
  • Demonstrates excellence in his/her own discipline and/or area of pursuit
  • Demonstrated strong aptitude to lead a group or team endeavour, and building team unity
  • Demonstrated project management experience
  • Skilled in designing research projects including short and long-term plans
  • Demonstrated ability to compile and analyse study data with limited oversight
  • Excellent verbal presentation and written skills
  • Demonstrated ability to solve complex problems to attain crucial project goals

Qualifications:

  • Ph.D. or M.Sc or B.Sc  with demonstrable experience
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Location: London (Kings Cross)

We are currently seeking a highly motivated Research Associate to join our Translational Research team. This position will report into the Senior Scientist – Translational Research.

The Research Associate will assist in the development and validation of immunoassays and cell-based assays (including pharmacokinetic, immunogenicity, biomarkers and others as needed). The scientist will work within Gyroscope’s research team to develop and oversee assays that will be used for internal developmental work or placed at Contract Research Organisations (CROs) or academic establishments. This scientist should be proactive, inquisitive and a self-starter who is eager to learn and thrives in fast paced environment.

The position will be primarily based in London although some travel to our facilities in Stevenage may be required.

Key Responsibilities

  • Hands-on development and validation of immunoassays and cell-based assays
  • Assist and/or train others when appropriate.
  • Evaluate new assay technologies and other applications for improved performance and efficiency of laboratory activities.
  • Preparation and maintenance of accurate laboratory records
  • Performs other duties as assigned

 What we will look for in your skills and experience:

  • Hands-on experience with cellular and biochemical immunoassays such as ELISA, western blotting, cell-based assays, qPCR
  • Experience of assays used to measure immunogenicity is an advantage
  • Experience in cell and tissue culture, working under aseptic conditions.
  • Experience working in a GLP/GCP compliant environment is preferred, although full training will be given if required.
  • Ability to prioritise and deliver projects on time
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Please apply with your CV and Cover Letter, highlighting your interest and relevant skills.

Location: London (Kings Cross)

We are currently seeking a highly motivated Senior Translational Scientist with strong a strong immunology background to join our Translational Research team. This position will report into the Scientific Director.

The Senior Translational Scientist will act as an expert in the development, validation, transfer, and troubleshooting of immunoassays and cell-based assays (including pharmacokinetic, immunogenicity, biomarkers and others as needed). The scientist will work with Gyroscope’s research and clinical teams to develop and oversee assays that will be used for internal developmental work or placed at Contract Research Organisations (CROs) or academic establishments. In addition, the scientist will anticipate obstacles related to methodology and will troubleshoot and resolve these obstacles. This scientist should be proactive, inquisitive and a self-starter who is eager to learn and thrives in fast paced environment.

The ideal candidate will have pharmaceutical industry experience in the development of biologics and be lab based. Ideally, this individual will have knowledge of relevant global health authority guidelines and industry practices relating to assay development and validation. Excellent communication practiced through oral, written and presentation skills is required.

The position will be primarily based in London although some travel to our facilities in Stevenage may be required.

Key Responsibilities

  • Develop, validate, transfer and troubleshoot immunoassays and cell-based assays internally and at contract research organisations
  • Provide scientific oversight to contracted immunoassays including review of validation protocols and reports.
  • Develop close and effective partnerships with other nonclinical and clinical pharmacology scientists, safety scientists, research scientists, clinicians and project teams to foster a collaborative work environment.
  • Complete projects and prepare reports appropriate for internal or external parties within agreed timelines.
  • Represent Translational Research within multidisciplinary project teams
  • Assist and/or train others when appropriate.
  • Evaluate new assay technologies and other applications for improved performance and efficiency of laboratory activities.
  • Prepare presentations and represent research internally and externally.
  • Maintain awareness of current developments in the field through comprehensive reading of the literature and attendance at appropriate scientific meetings.
  • May assist in the preparation of internal documents and Regulatory submissions, including authoring (under supervision)

Required attributes:

  • Working knowledge and hands on experience with a wide range of cellular and biochemical immunoassays and state-of-the-art molecular biology techniques is a must.
  • Expertise in immunogenicity-related and/or complement-related immunoassays is an advantage.
  • Experience with bioanalytical method development, validation and troubleshooting of immunochemistry and immunoassay techniques including multiplex approaches e.g. Luminex or MSD platforms.
  • Demonstrate scientific creativity, critical thinking, and analytical problem-solving skills, with a strong track record of research productivity as evidenced by high-quality publications.
  • Experience with guidelines and/or working in a GLP/GCP compliant environment.
  • Experience of working with biological samples obtained from clinical trials.
  • Experience of biomarker development.
  • Strong scientific skills with the ability to collaborate with project team members.
  • Excellent collaboration, communication and decision-making skills.
  • Demonstrated ability to solve complex problems to attain crucial project goals.

Qualifications:

  • Ph.D. in a Biological Science (e.g., Immunology, Biochemistry, Cell Biology, Bioanalytical or a related field) with relevant industry experience preferably within the biotech / pharmaceutical sector.
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Location: Ambler, PA

The Director of Regulatory Affairs will be responsible for taking the lead in delivering regulatory activities/submissions necessary to support global device development and registration, as well as supporting in the development of Gyroscope’s gene therapy portfolio.

The successful candidate will be part of a team that is developing innovative and pioneering technologies to treat a debilitating blinding diseases, which may become the standard of care in the future.

This position will report into the VP, Regulatory.

The key responsibilities of this role are:

  • Lead global regulatory activities to support all aspects of Gyroscope’s surgical device development, registration and commercialisation
  • Contribute to US regulatory activities supporting the development of Gyroscope’s gene therapy pipeline
  • Manage the preparation, submission and management of high-quality regulatory filings including but not limited to 510(k)’s, I513(g) Pre-Subs, IDES, EU Technical Files and CERs
  • Act as regulatory contact point Gyroscope’s interactions with external partners, consultants, CROs and regulatory authorities.
  • Contribute to the growth of Gyroscope’s regulatory affairs function, including regulatory operations, supporting compliance and inspections.
  • Remain expert and up to date on global regulatory requirements.
  • Keep abreast of relevant regulatory intelligence and ensuring this is effectively disseminated within the organisation.
  • Assist with training of staff in regulatory matters as required.

What we will look for in your experience and skills:

EXPERIENCE:

  • Solid demonstrable regulatory affairs experience in medical devices. Regulatory experience with biotechnological/biological products a plus.
  • Demonstrated Knowledge of regulatory requirements for EU CE Marking per MDD/MDR and IVDD/IVDR and for US FDA. Experience with 510(k). submissions, preferably with sole responsibility for completion.
  • A track record of successful interactions and submissions with regulatory agencies including FDA, as well as notified bodies.
  • Hands-on experience with EU Technical Files and knowledge of CE Marking requirements; Clinical Evaluation Report writing a plus.
  • Experience with other regulatory documents/submissions (US: 513(g), Pre-Subs, IDE; Canada: Class II-IV MDLs; EU: CERs).

Education

  • BA/BS in the life sciences or equivalent work experience is required.
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Location: Stevenage

Gyroscope is recruiting for a clinical scientist in ophthalmology to join the clinical development group. The clinical scientist is responsible for providing scientific expertise at the project and study level in support of clinical research and translational medicine in ophthalmology. He/she will collaborate with internal and external stakeholders to plan, implement, and manage clinical research studies to ensure trial integrity and success. Responsibilities include providing scientific input to clinical development, including study design and analysis plans; evaluating and interpreting clinical data; reviewing and authoring study-related documents; supporting external collaborations and clinical advisory boards; and developing and maintaining knowledge of therapeutic areas of interest. The clinical scientist will be a key contributor to cross-functional project teams focused on the development of gene therapies for ophthalmic diseases.

The key responsibilities will be:

  • Develop expertise on therapeutic areas of interest, including endpoints and biomarkers
  • Scientific literature review and summary
  • Contribute to the translational medicine and pharmacology team
  • Writing of clinical protocols
  • Preparation of annual reports, including safety updates
  • Review of incoming clinical data
  • Collaborate with external experts and consultants

What we look for in your experience and skills:

  • PhD or MD/PhD
  • Strong scientific background with good understanding of ocular disease biology
  • Clinical or translational experience in ophthalmology preferred
  • Experience in the principles and techniques of data analysis, interpretation and characterisation of clinical relevance
  • Experience of global drug development
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