Chris is the Chief Investment Officer and a Managing Partner of Syncona Investment Management Ltd. Chris is a member of the boards of three Syncona Portfolio companies, NightstaRx Limited, Freeline Therapeutics Limited and Gyroscope Therapeutics Limited. Previously, he was a partner of Apposite Capital LLP, a venture and growth capital company focused on the healthcare and life science sector. During his time at Apposite, he was involved in a number of investments, which included Ambit Biosciences (acquired by Daiichi Sankyo), Convergence Pharmaceuticals (acquired by Biogen-Idec), Birdrock and the acquisition of a portfolio of nine US healthcare companies which included Zonare Medical Systems (acquired by Mindray) and Ulthera (acquired by Merz). Before Apposite, Chris had roles with Bioscience Managers Ltd, Neptune Investment Management Ltd and as a medicinal chemist in the pharmaceutical industry. Chris holds a degree in Natural Sciences and a PhD in Organic Chemistry, both from Cambridge University
Khurem became Chief Executive Officer in 2019, bringing more than 20 years of experience in drug development and operational leadership to Gyroscope. He previously served as the Senior Vice President of the Immunology and Ophthalmology business unit at Genentech, a member of the Roche Group.
During his eleven-year tenure at Genentech, Khurem led the commercialization and launch planning of a number of medicines in the Immunology and Opthalomology area and helped move a number of medicines into the pipeline as a member of the Late Stage Portfolio Committee. He also was actively involved in a number of business development assessments for the organization.
Khurem began his career at Aventis in the United Kingdom holding various roles in sales and marketing, including leading several pan-European business initiatives at the European Headquarters in Paris.
Khurem holds a Master’s Degree in Business Administration as well as an Honors degree in Biological Sciences.
Soraya is a Board-certified MD with 20 years of experience in Drug Development across several therapeutic areas, with a focus on gene therapy and she leads the research and development of Gyroscope’s therapeutics pipeline. Between 2017 and March 2019 Soraya served as CEO and CMO of Gyroscope and led the company successfully to clinical stage.
Prior to joining Gyroscope, Soraya served as SVP Chief Medical Officer of Lysogene, a clinical stage biotech developing gene therapy products in rare central nervous system diseases. As a member of the executive team, she contributed to the successful listing of the company on the European Stock Exchange Euronext.
Prior to that Soraya held leadership positions within global research and development at Sanofi. As Development Head for a global gene therapy programme in peripheral artery disease, she led the only phase III gene therapy programme conducted in 30 countries over 5 continents. Subsequently she was appointed Chief Medical Officer of the newly created Ophthalmology Division when Sanofi acquired Biotech Fovea pharmaceuticals where she oversaw the clinical development, regulatory, health economics and programme management. In a broader capacity she took over the overall leadership of the Global Ophthalmology Division where she orientated the Sanofi strategy towards investing in ocular gene therapy, building up a pipeline of in-licensed or internal programs in inherited retinal dystrophies, or more prevalent conditions such as wet AMD, diabetic retinopathy, uveitis and glaucoma.
She holds a Medical Degree from Paris University and specialised in clinical pharmacology and biostatistics.
Ian Clark joined the board of directors of Gyroscope Therapeutics in 2019. Ian has more than 34 years of experience in the biotechnology and pharmaceutical industry, most recently serving as CEO and member of the board of directors for Genentech, a member of the Roche Group, until his retirement in 2016. During his seven-year tenure as CEO, Ian and his team brought eleven new medicines to market for patients fighting rheumatoid arthritis, idiopathic pulmonary fibrosis and various types of cancer. Ian was among the highest rated CEOs by Glassdoor, recognized as the Bay Area’s most admired CEO by the San Francisco Business Times and awarded the Honorable Mentor of the Year by the Heath Business Woman’s Association.
Prior to joining Genentech, Ian held various positions of increasing responsibility at Novartis, Sanofi, Ivax and Searle, working in the USA, UK, Canada, Eastern Europe and France.
Currently, Ian is on the board of directors for Takeda, Agios Pharmaceuticals, Guardant Health, Forty Seven, Avrobio and Corvus Pharmaceuticals. He is an Operating Partner of Blackstone Life Sciences. He is also on the BioFulcrum Board of the Gladsone Institute. Ian previously served on the board of directors of Shire, Kite Pharma, Dendreon, Solazyme and Vernalis. He was also on the Biotechnology Industry Association board of directors and on the Economic Advisory Council of the 12th District of the Federal Reserve.
Ian received his bachelor of science in Biological Sciences and an Honorary Doctorate of Science from Southampton University in the United Kingdom.
Iain joined Cambridge Enterprise in 2003. He manages the Life Science team that has a strong track record of spin out formation and licensing with a significant portfolio including alemtuzumab (Lemtrada) and spin-outs Mission Therapeutics, Cambridge Epigenetix, XO1 Therapeutics (sold to Janssen Pharmaceuticals), Z-factor and Phoremost. He led the Cambridge–GSK open innovation drug discovery initiative based at the SBC and was the Cambridge lead for the Apollo Therapeutics Fund.
David Kavanagh is the Professor of Complement Therapeutics at the National Renal Complement Therapeutics Centre (NRCTC). The NRCTC is a combined clinical, diagnostic and treatment centre for the complement mediated diseases: atypical haemolytic uraemic syndrome (aHUS) and C3 glomerulopathy. All patients in England treated with eculizumab for these diseases are managed through the NRCTC. His University research group has been at the forefront of defining the role of complement in renal disease and is fully integrated with the NRCTC to provide rapid translational benefits to patients. David moved to Newcastle to start his own lab in 2008 with a Wellcome Trust Fellowship following a Kidney Research UK Fellowship at the University of Edinburgh. He was previously a Fellow at Washington University School of Medicine, St. Louis. He graduated in Medicine and Immunology from the University of Glasgow in 1998 and obtained his PhD from Newcastle University in 2006. For his work defining the role of complement in aHUS, he was awarded the Renal Association’s Young Investigator (Raine) award. Additionally, he runs a glomerulonephritis and vasculitis clinic at Freeman hospital. He is chairman of the aHUS rare disease working group, an executive committee member of Complement UK
Gyroscope Therapeutics Ltd is developing cutting edge, genetically-defined therapies for the treatment of eye diseases linked to an unbalanced complement systemView More +
Gyroscope was founded to explore the convergence of advancements made in the understanding of the complement system’s impact on eye disease, the genetic basis of Age-related Macular Degeneration (AMD) and gene therapy as a mode of sustained treatment delivery.View More +