Careers

We provide extraordinary career opportunities for talented individuals, who will have the opportunity to work with highly experienced leaders in science and business with proven track records in building successful businesses.

Our success depends on the quality, experience and ambition of the individuals that join our team.

Open Positions

To take the next exciting step in your career, please review our list of current openings and job descriptions below. To apply, please submit your CV and a cover letter to recruitment@gyroscopetx.com

Gyroscope does not accept speculative applications from recruitment agencies.

 

We are currently seeking a highly motivated Research Scientist/Geneticist with a background in Genetics or Bioinformatics. Gyroscope’s mission is to develop genetically-defined therapies for the treatment of eye diseases linked to an unbalanced complement system. The company has built up a highly experienced and cross-disciplinary team and is developing cutting edge therapies for eye diseases with medical unmet need.
The successful candidate will join Gyroscope’s highly active research team which is responsible for the development of novel gene-based therapies from early in vitro and in vivo proof-of-concept to First-in-Man clinical studies. He or she will have a scientific background with relevant experience in genetic analysis/bioinformatics to reinforce the translational medicine approach sought by Gyroscope.

Typical responsibilities will include:
• Data mining of molecular data from all available sources, performing molecular analysis including identification and classification of sequence variants of specific genes of interest, genotyping results and any other data as indicated;
• Applying this analysis to the interpretation of clinical sequence results in the context of clinical trial patient selection, and documenting the findings in clinical reports;
• interpreting, reviewing or approving genetic lab results;
• communicating results of findings, for instance at conferences or in scientific journals;
• conducting or supervising lab research of other biologists or technicians working on genetics research projects (such as to assess functional impact of genetic variants or confirming phenotype of known variants).

The candidate must possess the following skills:
• Have a strong scientific background with a proven knowledge of current genomics technologies, applications and challenges in translation from research to drug discovery;
• Demonstrable statistical skills with experience of analysing large-scale genetic/genomic data;
• Independent working style with high self-motivation;
• Clear communicator with ability to prepare material for presentation, patent filing and manuscript publication.

The following skills are optional but highly desirable:
• Has direct research experience in one or more of the following modalities: immunology genetics (especially complement system), whole-exome sequencing/GWAS/genotyping data analysis, clinical assay development, biomarker identification, proteomics, gene therapy.

We understand that the perfect candidate does not necessarily combine all required/optional skills and encourage all interested candidates that fulfil at least some of the requirements to apply.
The application should include a one page cover letter outlining how you meet the required competencies for this role at Gyroscope Therapeutics as outlined in the job requirements above. This letter should be accompanied by a current C.V. Interested applicants should submit their applications to recruiment@gyroscopetx.com.

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We are currently seeking a highly motivated Scientific Director. Gyroscope’s mission is to develop genetically-defined therapies for the treatment of eye diseases linked to an unbalanced complement system. The company has built up a highly experienced and cross-disciplinary team and is developing cutting edge therapies for eye diseases with medical unmet need.

The successful candidate will join Gyroscope’s highly active research team which is responsible for the designing and conducting/overseeing the in vitro and in vivo proof-of-concept studies (PoC) for gene therapy candidates in pre-clinical development. He or she will draw on at least 10 years scientific experience to progress all aspects of the research projects from early phase to subsequent transition to clinical development, as well as supporting assay development.

 

The position will report directly to the VP Research and be based in Stevenage, Hertfordshire, UK.

 

Candidate must possess the following skills:

  • Have a strong scientific background with a proven knowledge of product development in a relevant industry. This includes at least 4-5 years hands-on experience in a research lab;
  • Have experience in the effective management and leadership of scientific projects, teams and CRO third parties;
  • Demonstrable ability to prepare material for presentation, patent filing and manuscript publication.

 

The following skills are optional but highly desirable:

  • Has direct research experience in one or more of the following specialities: therapeutic development, gene therapy vector platforms, drug delivery, immunology (especially complement system);
  • Experience in clinical assay development and/or genetic association studies;

 

Activities and responsibilities

The candidate will support the VP Research in delivering the Research goals at Gyroscope by assuming or demonstrating the following:

  • Under the responsibility of the VP Research, design and implement non-clinical studies to generate non-clinical proof-of-concept data and/or non-clinical safety evaluation;
  • Management of research team to identify, develop and characterise therapeutic gene therapy candidates in vitro and in vivo in relevant animal models;
  • Oversee the development of new assays and analytical techniques to answer research and/or clinical questions or improve current techniques;
  • Ensure all required documentation and reports are completed and approved in a timely manner, ensuring validity and reliability of data at all times;
  • Effective cross-functional interaction with other departments in Gyroscope;
  • Ability to prioritise research activities and deliver projects on time.
  • Ability to seek and leverage external expert opinions.

 

We understand that the perfect candidate does not necessarily combine all required/optional skills and encourage all interested candidates that fulfil at least some of the requirements to apply.

The application should include a one page cover letter outlining how you meet the required competencies for this role at Gyroscope Therapeutics as outlined in the job requirements above. This letter should be accompanied by a current C.V.  Interested applicants should submit their applications to recruitment@gyroscopetx.com.

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We are currently seeking a highly motivated Senior Research Immunologist with a strong background in Complement Biology.
The successful candidate will join Gyroscope’s highly active research team which is responsible for the development of novel gene-based therapies from early in vitro and in vivo proof-of-concept to First-in-Man clinical studies. He or she will have a scientific background with relevant experience in immunology (and the complement system if possible), to increase the group’s depth of knowledge and expertise in this key area.
Gyroscope’s mission is to develop genetically-defined therapies for the treatment of eye diseases linked to an unbalanced complement system. The company has built up a highly experienced and cross-disciplinary team and is developing cutting edge therapies for eye diseases with medical unmet need.
The position will be based in Stevenage, Hertfordshire, UK.

Candidate must possess the following skills:

• strong immunology background with proven knowledge of our current understanding of how proteins of the innate immune system participate in the activation and regulation of the complement system. This includes at least 4-5 years hands-on experience in a research lab;
• Have experience in the effective management of scientific teams and CRO third parties;
• Independent, hard working and highly motivated, able to deliver own tasks on time and inspire those around them into delivering theirs;
• Clear communicator with ability to prepare material for presentation, patent filing and manuscript publication.

The following skills are optional but highly desirable:
• Experience in product development or gene therapy, either in industry or academia;
• Experience in assay development (such as mass spec/proteomic-based assays, functional ELISA-based assays, cell-based assays);
• Background in ophthalmology or nephrology.

Activities and responsibilities
• Conduct or supervise research experiments to support early candidate evaluation and subsequent selection;
• Conduct or supervise the development of new assays and analytical techniques for nonclinical and clinical studies as required;
• Foster effective cross-functional interaction with other departments in Gyroscope;
• Demonstrable ability to prioritise and deliver projects on time.
• Ensure all required documentation and reports are completed and approved in a timely manner, ensuring validity and reliability of data at all times;

We understand that the perfect candidate does not necessarily combine all required/optional skills and encourage all interested candidates that fulfil at least some of the requirements to apply.
The application should include a one page cover letter outlining how you meet the required competencies for this role at Gyroscope Therapeutics as outlined in the job requirements above. This letter should be accompanied by a current C.V. Interested applicants should submit their applications to recruitment@gyroscopetx.com.

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Context and Responsibilities
• Working with the Senior Director of Clinical Operations and team to support the execution of clinical studies whether interventional or observational
• Monitoring of study deliverables
• Performing protocol-related site management activities
• Participating in study planning and set-up activities including vendor management, project management, and coordination of study and implementation plans
• Supporting vendor relationships

Activities
• Contribute to the design, content, and preparation of clinical protocols, amendments, consent forms, study guides, monitoring plans, CRFs, and subject information sheets as well as quality system maintenance for clinical programs.
• Assist in the identification of clinical trial investigators as required
• Coordinate and take direct responsibility for activities associated with site start-up and management including review site-modified informed consent templates. May be required to be involved in the tracking of the budget and contract process
• Monitor/Co-Monitor study sites
• Contribute to or coordinate preparation and conduct of monitors workshops and investigator meetings
• Work with the Senior Director of Clinical Operations and assigned CRO to develop recruitment strategies
• Provide input for screening and enrolment progress
• Coordinate study-level investigational product arrangements and accountability and reconciliation
• Participate in and support study teams and other cross-functional teams as necessary
• Provide clinical site/CRO, vendor support by answering protocol-specific questions
• Work with the Senior Director of Clinical Operations, and the CRO to resolve patient eligibility questions and protocol deviations
• Work with the CRO, the central lab and the Analytical team to coordinate shipment and analysis of clinical biological samples
• Support and monitor CRO and third party vendor activities, including relationships and training, and the development of vendor specifications and scopes of work
• Using relevant reports, identify progress of CRF data collection and query resolution
• Monitor progress of studies, identify study-related trends/issues and work with the Senior Director of Clinical Operations and CRO to implement corrective actions when necessary
• Support preparation and quality control of Clinical trial applications, clinical study reports, and regulatory submissions.
• Maintain correct information at Clinicaltrials.gov

Role Qualifications, Experience, Knowledge & Competencies
Basic Qualifications
• Life Sciences Degree
• Previous biopharmaceutical clinical operations experience (experience obtained working on industry-sponsored or industry-partnered clinical trials at academic institutions, or working on clinical trials at a biotech, pharmaceutical or CRO company)

Preferred Qualifications
• Broad experience in life sciences or medically related field, including general knowledge of biopharmaceutical clinical research
• Previous biopharmaceutical clinical operations experience (experience obtained working on industry-sponsored or industry-partnered clinical trials at academic institutions, or working on clinical trials at a biotech, pharmaceutical or CRO company)
• Ability to understand technical, scientific and medical information
• Understanding of drug development process
• Competent in clinical trial technologies (EDC, IVRS, WVRS, Vendor dashboards)
• Advanced computer skills
• Experience in interactions with vendors, e.g., CROs and contract labs
• Experience with administration of site budgets and grants with supervision
• Experience with development of prospective site-selection criteria
• Experience with reviewing adequacy of site-proposed ICs for compliance with relevant regulations
• Detailed knowledge of Good Clinical Practices (GCP), FDA regulations and guidelines, and applicable international regulatory requirements
• Ability to write and present clearly using scientific and clinical terminology
• Experience dealing with time demands, incomplete information and unexpected events
• Good organisational and planning skills
• Experience working effectively in a team/matrix environment
• Able to show initiative and creative thinking for problem solving

If interested please send your email and covering letter to recruitment@gyroscopetx.com

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We are currently seeking a highly motivated Research Scientist and/or Research Assistant. The successful candidate will join Gyroscope’s highly active research team which is responsible for the delivery of novel adeno-associated virus (AAV) construct designs and early in vitro and in vivo proof-of-concept studies (PoC) for candidates in pre-clinical development. He or she support all aspects of the projects from early phases and the subsequent transition to clinical development, as well as supporting subsequent vector manufacture and testing. The role will involve supporting the initiation and subsequent development of innovative improvements in the design, characterisation and manufacture of gene therapy medicines.

Required skills
• Experience in immunological techniques (such as ELISA, SDS-PAGE, western blot, FACS, immunofluorescence microscopy);
• Experience in cell and tissue culture, working under aseptic conditions;
• Experience in molecular techniques (such as cloning, agarose gel electrophoresis, alkaline gel electrophoresis);
• Preparation and maintenance of accurate laboratory records.

Optional skills
• Experience in assay development (particularly sandwich ELISA, cell-based assays, functional ELISA-based assays);
• Experience in gene therapy development or methods for the design and generation of biopharmaceutical viral vectors;
• Background in ophthalmology, immunology and/or complement research;
• Experience in industry.

Activities and responsibilities
• Conduct research experiments to support early candidate evaluation and subsequent selection;
• Development of new assays and analytical techniques to answer research questions or improve current techniques;
• Ensuring all required documentation and experimental records are completed and approved in a timely manner, ensuring validity and reliability of data at all times;
• Ability to prioritise and deliver projects on time;
• Effective cross-functional interaction with other departments in Gyroscope.

We understand that the perfect candidate does not necessarily combine all required/optional skills and encourage all interested candidates that fulfil at least some of the requirements to apply.

The application should include a one page cover letter outlining how you meet the required competencies for this role at Gyroscope Therapeutics as outlined in the job requirements above with a current C.V.

Apply +
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